I just read a fantastic article written by a physician who sees the need for real change in the way we live and eat as opposed to waiting for the "cure" via pharmaceuticals. He wrote:
A half century ago, there was dramatically less obesity. Very little about genes, metabolism or human nature has changed in the past five decades. We have epidemic childhood obesity now; we did not have it then. The ambient level of "personal responsibility" in 8 year olds has not changed over that span.
And: A dramatic change in the epidemiology of obesity is directly related to profound changes in our environments, food supply, activity levels and social norms. We have caused the obesity epidemic, by looking the other way as a staggering array of "advances" made ever more calories ever more temptingly available, and made physical activity ever more elusive.
I highly recommend you read his article over at Huffington Post. In my book I am writing about many similar principles.